An infusion system can be as simple as a needle and syringe or as complex as a catheter, port reservoir, Huber needle, jacket, tether, swivel, swivel holder, extension lines and pump. Just as the proper sized needle and appropriate volume syringe are necessary to achieve a simple IV injection, more complex systems also require the selection of components that best suit the infusion. Both complex and simple systems will function perfectly as quality infusion systems, but optimally, only under the right circumstances
When a researcher contacts us to determine which infusion system would be most suitable for their applications, they must first answer a number of questions relating to their unique requirements. The answers to these questions will dictate what components should be used to achieve their research objectives. By asking yourself these questions, finding the answers and understanding how they will affect your choices, you will be able to design your own systems.
Approaching infusion from a preclinical drug development standpoint, these important questions can be classified under two general categories; animal driven or test compound driven. There are a number of questions which do not fall under these categories that are also very important to answer during the planning stages of a study or project. These questions deal more with the reality of your circumstances and the compromises you may face rather than what would dictate the optimal system.
The animal driven questions are fewer and easier to answer. Standard research species, as you might expect, are used in greater numbers although the range of species is extremely wide. Since a test compound can be virtually anything, these questions are greater in number and the answers are usually not as readily available.
It is not uncommon that answers to these questions are unknown, by anyone, until days before the study is scheduled to begin. Unfortunately, sometimes these questions are not asked until after the study has begun or (even worse) completed. Needless to say, this jeopardizes not only the validity of the data but can lead to a senseless waste of animals.
Our goal at SAI is to help you consider these questions, determine the appropriate answers, and ultimately have the knowledge to create a successful infusion study. We'll work with you; guiding you through the options, weighing the pros and cons of the available tools, and sharing our knowledge along the way. Contact us at any time to get the conversation started.